Mdr1 gene washington state

She has published more than peer-reviewed articles. Katrina Mealey discovered a potentially fatal gene mutation in dogs, developed a test for it, and has established a unique program at WSU of individualized medical treatment for pets.

She discovered the MDR1 gene mutation and is the inventor of a subsequent genetic test for the mutation. Knowing a pet dog has the mutation prevents it from suffering from a profound and potentially fatal toxicity to certain medications a veterinarian might normally administer.

The program in individualized medicine PrIMe has established WSU as the preeminent institution in veterinary pharmacogenetics. PrIMe employs a dedicated core faculty, technical staff, and collaborators in the WSU College of Veterinary Medicine that optimizes drug therapy for individual patients. PrIMe faculty share their expertise via education and outreach activities for veterinarians, breeders, and the pet-owning public worldwide.

PrIMe is focusing on animals sensitive to known anesthetic agents and searching for gene mutations that, like the MDR1, can be used to predict and prevent serious adverse drug reactions. Also under study, and of perhaps greater concern, is the class of drugs known as non-steroidal anti-inflammatories or NSAIDs. Keith Moo-Young, a licensed Professional Engineer, led an industry consortium research project on manufactured gas plant remediation strategies for the Electric Power Research Institute that included 15 public utilities.

As a result, he shares a patent with colleagues Derick Brown and Andrew J. Coleman for a process to quantify coal tar in the environment. Test Your Dog with Blood Sample. Test Your Dog with Cheek Swab. WSU PrIMe pipeline: Progressive renal failure in cats-We anticipate offering a genetic test to determine if an individual cat is at high risk for developing chronic kidney failure.

J Vet Int Med epub. Clinicians Brief May online cliniciansbrief. Vet Comp Oncol Epub , Oct Identification of a nonsense mutation in feline ABCB1.

J Vet Pharm Ther ;38 5 Impact of the canine double-deletion b1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a b1-selective b-blocker. Pharmacogenet Genomics 25 9 Mealey KL , Fidel J. P-glycoprotein-mediated drug interactions in oncology patients.